Does this table on Moclobemide metabolism make sense? It was made on chatgpt.
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Moclobemide, plasma concentrations 2x-3x higher in poor metabolizers than extensive metabolizers
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28 days on moclobemide without any effect. I saw that it usually takes 4 to 6 weeks to notice a real effect.
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I took moclobemide for 5 days and didn't take it for 24 hours and continued normally every 12 hours. I've been without stopping for 3 weeks, should I count these 5 days that I stopped for 24 hours? The question is whether I missed these 5 days of treatment?
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I've been on moclobemide for 3 weeks, the first 5 days gave me terrible insomnia along with a headache, no benefits yet. But it seems like I'm more nervous, I'm fighting over anything, easily irritated, can this happen before Moclobemide kicks in and takes effect?
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Methylene blue - potent MAO inhibitor.
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I wonder how they haven't invented a quick test for tyramine with so much technology nowadays, something to have at home and take measurements.
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Phentolamine in hypertensive crisis, why does no one use it and no doctor talks about it? If it's on the leaflet.
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A meta-analysis says that depression has nothing to do with brain serotonin concentration, and serotonin is not the cause of depression, what do you think? So why do some antidepressants work?
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What is a generally recommended and good dose of melatonin for sleeping due to insomnia caused by MAOIs? Is immediate or prolonged release of melatonin and its dose better?
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We know that moclobemide is inferior in efficacy to other irreversible MAOIs, now compared to serotonin reuptakers, for example escitalopram, do you think that moclobemide is slightly better than them in terms of efficacy or an efficacy equal to or worse than serotonin reuptake inhibitors?
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Does moclobemide have to be taken 2x a day or 3x a day? Because the guideline is 2 or 3x, the question is if taking it 2x a day, will it have the same effect as taking 3x a day?
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Is milk kefir okay to drink with MAOI? Or is there a lot of tyramine in Kefir?
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My moclobemide came in a bottle, not in a blister, I cut it in half and half of it softened, it was very hard before, now I'm afraid that everything inside the bottle will soften, what do you do?
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Does Ursodiol interact with MAOi? Moclobemide, Parnate, Nardil! Is green propolis extract okay? These are two questions.
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Many say that anxiety and panic disorders are caused by excess norepinephrine and adrenaline, don't MAOIs increase these substances? Can anyone explain the mechanism of effectiveness for anxiety and panic, just MAOI inhibition?
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Has anyone done TMS together with MAOI? Is it more effective? TMS will have what additive effect with those on MAOI?
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¿Venden antidepresivo Moclobemida en farmacias de Uruguay?
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Não entendo porque Brasil está atrasado em aprovar medicamentos novos para depressão, por exemplo Auvelity, Psilocibina.
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I just found out that in Brazil they don't sell dextromethorphan alone, only in syrup together with Guainfenesin. It's even more complicated to make combinations.
A community to discuss the medicine "Auvelity"
Can anyone help me make combinations to get Auvelity? They don't sell Auvelity in Brazil, I'm having a hard time knowing which version of bupropion and dextromethorphan is the correct one.
A community to discuss the medicine "Auvelity"
For poor metabolizers of CYP2C19, which is a substrate for Moclobemide metabolism, how do you adjust the dose? Is it greatly influenced? Or can you take the dose listed on the package insert?
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Does moclobemide increase serotonin or norepinephrine more? Or does it increase both equally?
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Anyone from Brazil taking Auvelity?
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1I'm trying to find a way to sell Auvelity in Brazil. It's been going on for 3 years and it hasn't arrived here yet. Does anyone know if it will arrive in Brazil soon? I want to take Auvelity because it's been over 2 years.But it can't be bought in Brazil. Can anyone help me out?
A community to discuss the medicine "Auvelity"
